Endocrine Abstracts

Introduction: In small intestinal neuroendocrine tumors (SI-NET), unphysiological exposure to serotonin is considered as a major pathogenic factor predisposing to the development carcinoid heart disease (CHD), a complication of carcinoid syndrome associated with poor prognosis. The ability of biomarkers to predict the development of CHD is limited. The aim of our prospective study was to assess risk factors of CHD development and mortality in SI-NET.Meth...

Background20–30% of patients with metastatic small intestine neuroendocrine tumours (SI-NETs) suffer from carcinoid syndrome (CS), i.e. diarrhea, flushing, and bronchospasm. Of these, 25–50% develop carcinoid heart disease (CHD) characterized by valve fibrosis and right heart failure. There are no early predictive markers of CHD, which typically is diagnosed in the advanced stage.Aims of the studyTo...